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TRPS1 function beyond breast: A retrospective immunohistochemical study on non-breast cytology specimens.
- Source :
-
Diagnostic cytopathology [Diagn Cytopathol] 2024 Sep; Vol. 52 (9), pp. 499-504. Date of Electronic Publication: 2024 May 25. - Publication Year :
- 2024
-
Abstract
- Introduction: Trichorhinophalangeal syndrome type 1 (TRPS1) has emerged as a reliable immunohistochemistry (IHC) marker for identifying breast origin in metastatic carcinomas. This study investigates the utility of TRPS1 IHC in non-breast cytology specimens.<br />Materials and Methods: A retrospective search of our pathology database for the year 2021 identified fluids (pleural and peritoneal) and liver, lung and bone fine needle aspirations (FNAs) with surgical follow-up confirming non-breast metastatic carcinomas. Cell blocks from cases with sufficient neoplastic cells underwent immunostaining using a rabbit polyclonal antibody against human TRPS1. Cases lacking tumor on deeper levels after the original work-up were excluded from the study. Two pathologists independently interpreted the TRPS1 staining.<br />Results: Of 136 cases assessed, 31 (22.79%) exhibited positive TRPS1 staining, while 105 (77.21%) were nonreactive. Positivity rates were observed in tumors of Mullerian cell origin, gastrointestinal tract (GIT), and lung origin at 28.85%, 25%, and 21.57%, respectively. Of the tumors of Mullerian cell origin 10 (66.67%) were serous carcinomas, 4 (26.67%) were endometrioid carcinomas, and one (6.67%) was a clear cell carcinoma. Lung tumors comprised seven (63.64%) squamous cell carcinomas and four (36.36%) adenocarcinomas, while the gastrointestinal tumors consisted of 14 (80%) adenocarcinomas and one (20%) squamous cell carcinoma.<br />Conclusions: Although recognized as a sensitive marker for mammary carcinomas, TRPS1 immunostaining was also detected in Mullerian, lung, and GIT carcinomas. This highlights the significance of being cautious when depending solely on TRPS1 immunostaining to distinguish metastatic breast tumors.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Female
Humans
Male
Biopsy, Fine-Needle
Breast Neoplasms pathology
Breast Neoplasms metabolism
DNA-Binding Proteins metabolism
DNA-Binding Proteins genetics
Retrospective Studies
Transcription Factors metabolism
Biomarkers, Tumor isolation & purification
Biomarkers, Tumor metabolism
Immunohistochemistry methods
Repressor Proteins isolation & purification
Repressor Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0339
- Volume :
- 52
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Diagnostic cytopathology
- Publication Type :
- Academic Journal
- Accession number :
- 38794964
- Full Text :
- https://doi.org/10.1002/dc.25359