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Risk factors for pneumonia among children with coinfection of influenza A virus and Mycoplasma pneumoniae.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Jul; Vol. 43 (7), pp. 1437-1444. Date of Electronic Publication: 2024 May 24. - Publication Year :
- 2024
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Abstract
- Objective: To investigate the clinical characteristics and risk factors for pneumonia in children co-infected with influenza A virus (IAV) and Mycoplasma pneumoniae (MP).<br />Methods: Children who were diagnosed with IAV and MP infection between January and December, 2023 were enrolled and divided into a non-pneumonia group and a pneumonia group. Univariate analysis and logistic regression analysis were used to evaluate each index, and the risk factors for pneumonia caused by coinfection in the two groups were explored.<br />Results: A total of 209 patients were enrolled, of which 107 and 102 patients were in the pneumonia and non-pneumonia groups, respectively. The patients in the pneumonia group were older and had a longer duration of fever (P < 0.05). Univariate analysis revealed that the median age, duration of fever, and CD3 <superscript>+</superscript> , CD4 <superscript>+</superscript> , CD8 <superscript>+</superscript> and IL-10 levels were significantly correlated with pneumonia (P < 0.05). Multivariate logistic regression analysis revealed that the median age, duration of fever, and CD4 <superscript>+</superscript> , CD8 <superscript>+</superscript> and IL-10 levels were independent risk factors for pneumonia. Area under the curve of the five combined indicators in the ROC (receiver operator characteristic) analysis was 0.883, was higher than single factor.<br />Conclusion: Children with IAV and MP infection whose age older than 6.08 years, had a fever longer than 4 days, had a CD4 <superscript>+</superscript> count < 22.12%, had a CD8 <superscript>+</superscript> count < 35.21%, had an IL-10 concentration > 22.08 ng/ml were more likely to develop pneumonia.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38789887
- Full Text :
- https://doi.org/10.1007/s10096-024-04854-3