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Differences in factors associated with insomnia symptoms between patients with epilepsy with and without depressive symptoms.
- Source :
-
Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Jul; Vol. 156, pp. 109781. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Objective: To determine if insomnia-related factors differ depending on the presence of depression in patients with epilepsy.<br />Methods: This cross-sectional multicenter study collected data on depressive symptoms, insomnia symptoms, and excessive daytime sleepiness, which were defined as a Patient Health Questionnaire-9 (PHQ-9) score of ≥ 10, an Insomnia Severity Index (ISI) score of ≥ 15, and an Epworth Sleepiness Scale (ESS) of ≥ 11, respectively. Further, uncontrolled seizures were defined as one or more seizures per month during antiseizure medications treatment. A stepwise logistic regression analysis was conducted, with a logistic regression with interaction terms performed to identify differences in insomnia-related factors depending on depressive symptoms.<br />Results: Of 282 adults with epilepsy (men, 58 %; mean age, 40.4 ± 13.9 years), a PHQ-9 score ≥ 10, an ISI score ≥ 15, an ESS score ≥ 11 were noted in 23.4 % (n = 66), 20.2 % (n = 57), and 12.8 % (n = 36), respectively. More patients with depressive symptoms had an ISI score ≥ 15 (56.1 % vs. 9.3 %; p < 0.001) than those without. In multiple logistic regression, uncontrolled seizures (odds ratio [OR], 4.896; p < 0.01), daytime sleepiness (OR, 5.369; p < 0.05), and a history of psychiatric disorders (OR, 3.971; p < 0.05) were identified as significant factors that were more likely to be associated with an ISI score ≥ 15; however, this was only true in patients without depressive symptoms. In contrast, use of perampanel (OR, 0.282; p < 0.05) was less likely associated, while female sex (OR, 3.178; p < 0.05) was more likely associated with an ISI score ≥ 15 only in patients with depressive symptoms.<br />Conclusions: Insomnia-related factors in patients with epilepsy may differ between patients with and without depression. Our findings of different insomnia-related factors based on the presence of depression may facilitate the management of patients with epilepsy.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Adult
Cross-Sectional Studies
Middle Aged
Young Adult
Logistic Models
Anticonvulsants therapeutic use
Surveys and Questionnaires
Severity of Illness Index
Sleep Initiation and Maintenance Disorders complications
Sleep Initiation and Maintenance Disorders psychology
Epilepsy complications
Epilepsy psychology
Depression epidemiology
Depression complications
Subjects
Details
- Language :
- English
- ISSN :
- 1525-5069
- Volume :
- 156
- Database :
- MEDLINE
- Journal :
- Epilepsy & behavior : E&B
- Publication Type :
- Academic Journal
- Accession number :
- 38788656
- Full Text :
- https://doi.org/10.1016/j.yebeh.2024.109781