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Biosynthesis of isonitrile lipopeptides.
- Source :
-
Current opinion in chemical biology [Curr Opin Chem Biol] 2024 Aug; Vol. 81, pp. 102470. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α-ketoglutarate dependent dioxygenases has intrigued several research groups to investigate their catalytic mechanism. Here we summarize the recent studies on the biosynthesis of isonitrile lipopeptides from Streptomyces and Mycobacterium. The latest research on the core and tailoring enzymes involved in the pathway as well as the isonitrile metabolic enzymes are discussed in this review.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interest or conflict of interest that could have appeared to influence the work reported in this article.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0402
- Volume :
- 81
- Database :
- MEDLINE
- Journal :
- Current opinion in chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 38788523
- Full Text :
- https://doi.org/10.1016/j.cbpa.2024.102470