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Protective Effects of an Oligo-Fucoidan-Based Formula against Osteoarthritis Development via iNOS and COX-2 Suppression following Monosodium Iodoacetate Injection.
- Source :
-
Marine drugs [Mar Drugs] 2024 May 06; Vol. 22 (5). Date of Electronic Publication: 2024 May 06. - Publication Year :
- 2024
-
Abstract
- Osteoarthritis (OA) is a debilitating joint disorder characterized by cartilage degradation and chronic inflammation, accompanied by high oxidative stress. In this study, we utilized the monosodium iodoacetate (MIA)-induced OA model to investigate the efficacy of oligo-fucoidan-based formula (FF) intervention in mitigating OA progression. Through its capacity to alleviate joint bearing function and inflammation, improvements in cartilage integrity following oligo-fucoidan-based formula intervention were observed, highlighting its protective effects against cartilage degeneration and structural damage. Furthermore, the oligo-fucoidan-based formula modulated the p38 signaling pathway, along with downregulating cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, contributing to its beneficial effects. Our study provides valuable insights into targeted interventions for OA management and calls for further clinical investigations to validate these preclinical findings and to explore the translational potential of an oligo-fucoidan-based formula in human OA patients.
- Subjects :
- Animals
Mice
Cartilage, Articular drug effects
Cartilage, Articular pathology
Disease Models, Animal
Iodoacetates
Iodoacetic Acid
Oxidative Stress drug effects
Rats
Cyclooxygenase 2 Inhibitors chemistry
Cyclooxygenase 2 Inhibitors pharmacology
Cyclooxygenase 2 metabolism
Nitric Oxide Synthase Type II antagonists & inhibitors
Nitric Oxide Synthase Type II metabolism
Osteoarthritis drug therapy
Osteoarthritis chemically induced
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 38786602
- Full Text :
- https://doi.org/10.3390/md22050211