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Chemotherapy Primary Dose Reduction in Older Cancer Patients: A Retrospective Cohort.
- Source :
-
Cancer investigation [Cancer Invest] 2024 May; Vol. 42 (5), pp. 416-424. Date of Electronic Publication: 2024 May 24. - Publication Year :
- 2024
-
Abstract
- Primary dose reduction (PDR) in the first course of chemotherapy is an empirical practice, commonly used in older population. Patients over 70 years old receiving a first course of chemotherapy for a solid tumor were enrolled. A total of 179 patients were included. Standard dose was used in 69.8% of patients, while 30.2% received PDR of chemotherapy. Only 29.6% received a standardized geriatric assessment. Patients receiving standard doses presented 83.2% of toxicities, while 68% of toxicities were reported in patients receiving PDR. The toxicity rate was significantly decreased in patients treated with reduced first-cycle dose of chemotherapy.
- Subjects :
- Humans
Aged
Male
Female
Retrospective Studies
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Antineoplastic Combined Chemotherapy Protocols adverse effects
Antineoplastic Agents adverse effects
Antineoplastic Agents administration & dosage
Antineoplastic Agents therapeutic use
Geriatric Assessment
Dose-Response Relationship, Drug
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4192
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer investigation
- Publication Type :
- Academic Journal
- Accession number :
- 38785096
- Full Text :
- https://doi.org/10.1080/07357907.2024.2357166