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A Coalescing Filter for Liquid-Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry.

Authors :
Daglish J
Blacker AJ
de Boer G
Russell SJ
Tausif M
Hose DRJ
Parsons AR
Crampton A
Kapur N
Source :
Organic process research & development [Org Process Res Dev] 2024 May 06; Vol. 28 (5), pp. 1979-1989. Date of Electronic Publication: 2024 May 06 (Print Publication: 2024).
Publication Year :
2024

Abstract

Presented here is the design and performance of a coalescing liquid-liquid filter, based on low-cost and readily available meltblown nonwoven substrates for separation of immiscible phases. The performance of the coalescer was determined across three broad classes of fluid mixtures: (i) immiscible organic/aqueous systems, (ii) a surfactant laden organic/aqueous system with modification of the type of emulsion and interfacial surface tension through the addition of sodium chloride, and (iii) a water-acetone/toluene system. The first two classes demonstrated good performance of the equipment in effecting separation, including the separation of a complex emulsion system for which a membrane separator, operating through transport of a preferentially wetting fluid through the membrane, failed entirely. The third system was used to demonstrate the performance of the separator within a multistage liquid-liquid counterflow extraction system. The performance, robust nature, and scalability of coalescing filters should mean that this approach is routinely considered for liquid-liquid separations and extractions within the fine chemical and pharmaceutical industry.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2024 The Authors. Published by American Chemical Society.)

Details

Language :
English
ISSN :
1083-6160
Volume :
28
Issue :
5
Database :
MEDLINE
Journal :
Organic process research & development
Publication Type :
Academic Journal
Accession number :
38783854
Full Text :
https://doi.org/10.1021/acs.oprd.4c00012