Back to Search
Start Over
In vitro and in vivo efficacy of the amiodarone and praziquantel combination against the blood fluke Schistosoma mansoni .
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0011424. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Schistosomiasis, a widespread parasitic disease caused by the blood fluke of the genus Schistosoma , affects over 230 million people, primarily in developing countries. Praziquantel, the sole drug currently approved for schistosomiasis treatment, demonstrates effectiveness against patent infections. A recent study highlighted the antiparasitic properties of amiodarone, an anti-arrhythmic drug, exhibiting higher efficacy than praziquantel against prepatent infections. This study assessed the efficacy of amiodarone and praziquantel, both individually and in combination, against Schistosoma mansoni through comprehensive in vitro and in vivo experiments. In vitro experiments demonstrated synergistic activity (fractional inhibitory concentration index ≤0.5) for combinations of amiodarone with praziquantel. In a murine model of schistosomiasis featuring prepatent infections, treatments involving amiodarone (200 or 400 mg/kg) followed by praziquantel (200 or 400 mg/kg) yielded a substantial reduction in worm burden (60%-70%). Given the low efficacy of praziquantel in prepatent infections, combinations of amiodarone with praziquantel may offer clinical utility in the treatment of schistosomiasis.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Mice
Female
Anthelmintics pharmacology
Anthelmintics therapeutic use
Drug Synergism
Drug Therapy, Combination
Male
Disease Models, Animal
Amiodarone pharmacology
Amiodarone therapeutic use
Praziquantel pharmacology
Praziquantel therapeutic use
Schistosoma mansoni drug effects
Schistosomiasis mansoni drug therapy
Schistosomiasis mansoni parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 68
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 38780260
- Full Text :
- https://doi.org/10.1128/aac.00114-24