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Zeolite-Loaded Hydrogels as Wound pH-Modulating Dressings for Diabetic Wound Healing.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2024 May 23. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Wound pH has emerged as a promising therapeutic target in diabetic foot ulcers (DFU). Here, we aimed to develop a microparticle-loaded hydrogel for pH modulation in wound fluid. In a screen of polymeric and inorganic microparticles, zeolites were identified as pH-modulating microparticles. Zeolites were encapsulated in a calcium cross-linked alginate hydrogel, a biocompatible matrix clinically used as a wound dressing. This hydrogel potently neutralized hydroxide ions in serum-containing simulated wound fluid. These findings encourage a further development of this pH-modulating device as a molecular therapeutic system for DFUs.
Details
- Language :
- English
- ISSN :
- 2576-6422
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 38780130
- Full Text :
- https://doi.org/10.1021/acsabm.4c00332