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Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
- Source :
-
European journal of histochemistry : EJH [Eur J Histochem] 2024 May 22; Vol. 68 (2). Date of Electronic Publication: 2024 May 22. - Publication Year :
- 2024
-
Abstract
- Osteoarthritis (OA) is a common degenerative joint disease in the elderly, while oxidative stress-induced chondrocyte degeneration plays a key role in the pathologic progression of OA. One possible reason is that the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which acts as the intracellular defense factor against oxidative stress, is significantly inhibited in chondrocytes. Spinosin (SPI) is a potent Nrf2 agonist, but its effect on OA is still unknown. In this study, we found that SPI can alleviate tert-Butyl hydroperoxide (TBHP)-induced extracellular matrix degradation of chondrocytes. Additionally, SPI can effectively activate Nrf2, heme oxygenase-1 (HO-1), and NADPH quinone oxidoreductase 1 (NQO1) in chondrocytes under the TBHP environment. When Nrf2 was silenced by siRNA, the cartilage protective effect of SPI was also weakened. Finally, SPI showed good alleviative effects on OA in mice. Thus, SPI can ameliorate oxidative stress-induced chondrocyte dysfunction and exhibit a chondroprotective effect through activating the Nrf2/HO-1 pathway, which may provide a novel and promising option for the treatment of OA.
- Subjects :
- Animals
Male
Mice
Membrane Proteins
Mice, Inbred C57BL
Oxidative Stress drug effects
tert-Butylhydroperoxide
Chondrocytes drug effects
Chondrocytes pathology
Heme Oxygenase-1 metabolism
NF-E2-Related Factor 2 antagonists & inhibitors
NF-E2-Related Factor 2 metabolism
Osteoarthritis chemically induced
Osteoarthritis drug therapy
Osteoarthritis pathology
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2038-8306
- Volume :
- 68
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of histochemistry : EJH
- Publication Type :
- Academic Journal
- Accession number :
- 38779782
- Full Text :
- https://doi.org/10.4081/ejh.2024.4033