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Nasal carriage of virulent and multidrug resistant Staphylococcus aureus: a possible comorbidity of COVID-19.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2024 May 22; Vol. 51 (1), pp. 665. Date of Electronic Publication: 2024 May 22. - Publication Year :
- 2024
-
Abstract
- Background: Staphylococcus aureus (S. aureus) associated with COVID-19 has not been well documented. This cross-sectional study evaluated the association between nasal S. aureus carriage and COVID-19.<br />Methods and Results: Nasopharyngeal samples were collected from 391 participants presenting for COVID-19 test in Lagos, Nigeria, and S. aureus was isolated from the samples. Antimicrobial susceptibility test was done by disc diffusion method. All S. aureus isolates were screened for the presence of mecA, panton-valentine leucocidin (PVL) and toxic shock syndrome toxin (TSST) virulence genes by polymerase chain reaction. Staphylococcal protein A (spa) typing was conducted for all the isolates. Participants with COVID-19 had double the prevalence of S. aureus (42.86%) compared to those who tested negative (20.54%). A significant association was seen between S. aureus nasal carriage and COVID-19 (pā=ā0.004). Antimicrobial sensitivity results showed resistance to oxacillin (100%), cefoxitin (53%), and vancomycin (98.7%). However, only 41% of the isolates harbored the mecA gene, with SCCmecV being the most common SCCmec type. There was no association between the carriage of virulence genes and COVID-19. A total of 23 Spa types were detected, with t13249 and t095 being the two most common spa types.<br />Conclusion: This study examined the association between nasal S. aureus carriage and SARS-COV-2 infection. Further research is required to fully explore the implications of S. aureus co-infection with COVID-19.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Subjects :
- Humans
Cross-Sectional Studies
Male
Female
Adult
Middle Aged
Bacterial Toxins genetics
Methicillin-Resistant Staphylococcus aureus genetics
Methicillin-Resistant Staphylococcus aureus isolation & purification
Methicillin-Resistant Staphylococcus aureus pathogenicity
Methicillin-Resistant Staphylococcus aureus drug effects
Comorbidity
Bacterial Proteins genetics
Virulence genetics
Nigeria epidemiology
Drug Resistance, Multiple, Bacterial genetics
Anti-Bacterial Agents pharmacology
Carrier State epidemiology
Carrier State microbiology
Microbial Sensitivity Tests
Penicillin-Binding Proteins genetics
Leukocidins genetics
Exotoxins genetics
Virulence Factors genetics
Young Adult
COVID-19 microbiology
COVID-19 epidemiology
COVID-19 virology
Staphylococcal Infections epidemiology
Staphylococcal Infections microbiology
Staphylococcus aureus genetics
Staphylococcus aureus drug effects
Staphylococcus aureus pathogenicity
Staphylococcus aureus isolation & purification
SARS-CoV-2 genetics
SARS-CoV-2 isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 38777940
- Full Text :
- https://doi.org/10.1007/s11033-024-09578-3