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Current progress of CAR-T-cell therapy for patients with multiple myeloma.
- Source :
-
International journal of hematology [Int J Hematol] 2024 Jul; Vol. 120 (1), pp. 15-22. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Currently available chimeric antigen receptor (CAR)-engineered T-cell therapies targeting B-cell maturation antigen (BCMA), namely, idecabtagene vicleucel and ciltacabtagene autoleucel, have shown marked efficacy against relapsed and refractory multiple myeloma. However, further improvement in CAR-T-cell function is warranted as most patients treated with these products eventually relapse due to various mechanisms such as antigen loss and T-cell dysfunction or disappearance. Strategies for improving CAR-T-cell function include targeting of dual antigens, enhancing cell longevity through genetic modification, and eliminating the immunosuppressive tumor microenvironment. Serious side effects can also occur after CAR-T-cell infusions. Although understanding of the molecular pathogenesis of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome is growing, the unique movement disorder caused by BCMA-targeted therapy is less understood, and its molecular mechanisms must be further elucidated to establish better management strategies. In this article, we will review the current status of BCMA-targeting CAR-T-cell therapy. We will also highlight progress in the development of CAR-T cells targeting other antigens, as well as universal allogeneic CAR-T cells and bispecific antibodies.<br /> (© 2024. Japanese Society of Hematology.)
- Subjects :
- Humans
T-Lymphocytes immunology
T-Lymphocytes transplantation
Tumor Microenvironment immunology
Cytokine Release Syndrome etiology
Cytokine Release Syndrome therapy
Multiple Myeloma therapy
Multiple Myeloma immunology
Immunotherapy, Adoptive methods
Immunotherapy, Adoptive adverse effects
B-Cell Maturation Antigen immunology
Receptors, Chimeric Antigen immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 120
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 38777913
- Full Text :
- https://doi.org/10.1007/s12185-024-03794-0