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Elevated circulating soluble interleukin-2 receptor (sCD25) level is associated with prefrontal excitatory-inhibitory imbalance in individuals with chronic pain: A proton MRS study.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 1-9. Date of Electronic Publication: 2024 May 19. - Publication Year :
- 2024
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Abstract
- Aberrant neuronal excitability in the anterior cingulate cortex (ACC) is implicated in cognitive and affective pain processing. Such excitability may be amplified by activated circulating immune cells, including T lymphocytes, that interact with the central nervous system. Here, we conducted a study of individuals with chronic pain using magnetic resonance spectroscopy (MRS) to investigate the clinical evidence for the interaction between peripheral immune activation and prefrontal excitatory-inhibitory imbalance. In thirty individuals with chronic musculoskeletal pain, we assessed markers of peripheral immune activation, including soluble interleukin-2 receptor alpha chain (sCD25) levels, as well as brain metabolites, including Glx (glutamate + glutamine) to GABA+ (γ-aminobutyric acid + macromolecules/homocarnosine) ratio in the ACC. We found that the circulating level of sCD25 was associated with prefrontal Glx/GABA+. Greater prefrontal Glx/GABA+ was associated with higher pain catastrophizing, evaluative pain ratings, and anxiodepressive symptoms. Further, the interaction effect of sCD25 and prefrontal Glx/GABA+ on pain catastrophizing was significant, indicating the joint association of these two markers with pain catastrophizing. Our results provide the first evidence suggesting that peripheral T cellular activation, as reflected by elevated circulating sCD25 levels, may be linked to prefrontal excitatory-inhibitory imbalance in individuals with chronic pain. The interaction between these two systems may play a role as a potential mechanism underlying pain catastrophizing. Further prospective and treatment studies are needed to elucidate the specific role of the immune and brain interaction in pain catastrophizing.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Gyrus Cinguli metabolism
Glutamic Acid metabolism
Glutamic Acid blood
Proton Magnetic Resonance Spectroscopy
Glutamine metabolism
Glutamine blood
gamma-Aminobutyric Acid metabolism
Catastrophization metabolism
Chronic Pain metabolism
Prefrontal Cortex metabolism
Interleukin-2 Receptor alpha Subunit metabolism
Interleukin-2 Receptor alpha Subunit blood
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2139
- Volume :
- 120
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 38772429
- Full Text :
- https://doi.org/10.1016/j.bbi.2024.05.020