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A Notch toward Progenitor D(G)FRentiation: Defining a NOTCH-PDGFR axis in brown adipogenesis.
- Source :
-
Developmental cell [Dev Cell] 2024 May 20; Vol. 59 (10), pp. 1231-1232. - Publication Year :
- 2024
-
Abstract
- Brown adipocytes are found in several fat depots, however, the origins and contributions of different lineages of adipogenic progenitor cells (APCs) to these depots are unclear. In this issue of Developmental Cell, Shi et al. show that platelet-derived growth factor receptor β (PDGFRβ)-lineage and T-box transcription factor 18 (TBX18)-lineage APCs differentially contribute to brown adipogenesis across these depots.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Adipose Tissue, Brown metabolism
Adipose Tissue, Brown cytology
Humans
Adipocytes, Brown metabolism
Adipocytes, Brown cytology
Receptor, Platelet-Derived Growth Factor beta metabolism
Receptor, Platelet-Derived Growth Factor beta genetics
Cell Differentiation
Cell Lineage
Mice
Signal Transduction
Adipogenesis physiology
Receptors, Notch metabolism
Stem Cells metabolism
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 59
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 38772342
- Full Text :
- https://doi.org/10.1016/j.devcel.2024.04.017