Back to Search
Start Over
Severe mental illness and mortality in sepsis and septic shock: a systematic review and meta-analysis.
- Source :
-
Molecular psychiatry [Mol Psychiatry] 2024 May 20. Date of Electronic Publication: 2024 May 20. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Background: There have been conflicting reports regarding the case-fatality outcomes associated with sepsis and septic shock in patients with severe mental illness (SMI).<br />Methods: We searched Medline®, Web of Science® and the Cochrane Library® databases (from inception to 4-July-2023) for papers reporting outcomes associated with sepsis and septic shock in adult with (cases) vs. without SMI (controls). The main study outcome was the unadjusted case-fatality rate at hospital discharge, or 30 days if unavailable. Secondary outcomes included the rates of adjusted case-fatality at hospital discharge.<br />Results: A total of six studies were included in the systematic review, of which four provided data for meta-analysis involving 2,124,072 patients. Compared to controls, patients with SMI were younger and more frequently women. Unadjusted analyses showed that SMI patients had a lower case-fatality rate associated with sepsis and septic shock than their non-SMI counterparts (OR 0.61, 95% CI [0.58-0.65], PI 95% CI [0.49-0.77], I <superscript>2</superscript> = 91%). Meta-regression and subgroup analyses showed that the denominator of the study population (i.e. septic shock or sepsis) was associated with the outcome with an R <superscript>2</superscript> of 59.7%.<br />Conclusion: In conclusion, our study reveals a survival advantage of SMI patients over their non-SMI counterparts. Further research is needed to fully elucidate the mechanisms involved and to develop targeted interventions that can improve the prognosis of both SMI and non-SMI patients facing sepsis.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Details
- Language :
- English
- ISSN :
- 1476-5578
- Database :
- MEDLINE
- Journal :
- Molecular psychiatry
- Accession number :
- 38769373
- Full Text :
- https://doi.org/10.1038/s41380-024-02603-8