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The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis.
- Source :
-
Cell death & disease [Cell Death Dis] 2024 May 20; Vol. 15 (5), pp. 347. Date of Electronic Publication: 2024 May 20. - Publication Year :
- 2024
-
Abstract
- Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. High expression level of YY1 has been reported in CRC, indicating the existence of stable factors of YY1 in CRC cells. We aimed to identify the key molecules and underlying mechanisms responsible for stabilizing YY1 expression in CRC. Mass spectrometry analysis was utilized to identify USP7 as a potential molecule that interacted with YY1. Mechanically, USP7 stabilizes YY1 expression at the protein level by interfering its K63 linkage ubiquitination. YY1 exerts its oncogenic function through transcriptionally activating TRIAP1 but suppressing LC3B. In addition, at the pathological level, there is a positive correlation between the expression of YY1 and the budding of CRC. This study has revealed the intricate interplay between YY1 and USP7 in CRC, suggesting that they could serve as novel therapeutic targets or predictive biomarkers for CRC patients.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Animals
Neoplasm Metastasis
Mice, Nude
Ubiquitination
Mice
Cell Movement
Male
Protein Binding
YY1 Transcription Factor metabolism
YY1 Transcription Factor genetics
Colorectal Neoplasms pathology
Colorectal Neoplasms metabolism
Colorectal Neoplasms genetics
Ubiquitin-Specific Peptidase 7 metabolism
Ubiquitin-Specific Peptidase 7 genetics
Cell Proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 38769122
- Full Text :
- https://doi.org/10.1038/s41419-024-06740-4