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A comprehensive analysis of the immune system in healthy Vietnamese people.

Authors :
Huynh DC
Nguyen MP
Ngo DT
Nguyen XH
Nguyen DT
Mai TH
Le TH
Hoang MD
Le KL
Nguyen KQ
Nguyen VH
Kelley KW
Source :
Heliyon [Heliyon] 2024 May 05; Vol. 10 (9), pp. e30647. Date of Electronic Publication: 2024 May 05 (Print Publication: 2024).
Publication Year :
2024

Abstract

Lifestyle, diet, socioeconomic status and genetics all contribute to heterogeneity in immune responses. Vietnam is plagued with a variety of health problems, but there are no available data on immune system values in the Vietnamese population. This study aimed to establish reference intervals for immune cell parameters specific to the healthy Vietnamese population by utilizing multi-color flow cytometry (MCFC). We provide a comprehensive analysis of total leukocyte count, quantitative and qualitative shifts within lymphocyte subsets, serum and cytokine and chemokine levels and functional attributes of key immune cells including B cells, T cells, natural killer (NK) cells and their respective subpopulations. By establishing these reference values for the Vietnamese population, these data contribute significantly to our understanding of the human immune system variations across diverse populations. These data will be of substantial comparative value and be instrumental in developing personalized medical approaches and optimizing diagnostic strategies for individuals based on their unique immune profiles.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2024 VinUniversity.)

Details

Language :
English
ISSN :
2405-8440
Volume :
10
Issue :
9
Database :
MEDLINE
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
38765090
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e30647