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A universal nanoreactor triggering butterfly effect for encouraging Fenton/Fenton-like reactions and chemodynamic therapy.
- Source :
-
Journal of colloid and interface science [J Colloid Interface Sci] 2024 Sep 15; Vol. 670, pp. 297-310. Date of Electronic Publication: 2024 May 15. - Publication Year :
- 2024
-
Abstract
- Fenton/Fenton-like reaction induced chemical dynamic therapy (CDT) has been widely recognized in tumor therapy. Due to the low efficiency of conversion from high-valent metal ions (M <superscript>(</superscript> <superscript>n</superscript> <superscript>+1)+</superscript> ) to low-valent ions (M <superscript>n</superscript> <superscript>+</superscript> ) in the Fenton/Fenton-like catalytic process, enhancing the conversion efficiency safely and effectively would create a great opportunity for the clinical application of CDT. In the study, a universal nanoreactor (NR) consisting of liposome (Lip), tumor cell membrane (CM), and bis(2,4,5-trichloro-6-carboxyphenyl) oxalate (CPPO) is developed to tackle this challenge. The CPPO was first discovered to decompose under weak acidity and H <subscript>2</subscript> O <subscript>2</subscript> conditions to generate carboxylic acids (R'COOH) and alcohols (R'OH) with reducibility, which will reduce M <superscript>(</superscript> <superscript>n</superscript> <superscript>+1)+</superscript> to M <superscript>n</superscript> <superscript>+</superscript> and magnify the effect of CDT. Furthermore, glucose oxidase (GOx) was introduced to decompose glucose in tumor and generate H <subscript>2</subscript> O <subscript>2</subscript> and glucose acid, which promote the degradation of CPPO, further strengthening the efficiency of CDT, leading to a butterfly effect. This demonstrated that the butterfly effect triggered by NR and GOx encourages Fenton/Fenton-like reactions of Fe <subscript>3</subscript> O <subscript>4</subscript> and MoS <subscript>2</subscript> , thereby enhancing the tumor inhibition effect. The strategy of combining GOx and CPPO to strengthen the Fenton/Fenton-like reaction is a universal strategy, which provides a new and interesting perspective for CPPO in the application of CDT, reflecting the exquisite integration of Fenton chemistry and catalytic medicine.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1095-7103
- Volume :
- 670
- Database :
- MEDLINE
- Journal :
- Journal of colloid and interface science
- Publication Type :
- Academic Journal
- Accession number :
- 38763026
- Full Text :
- https://doi.org/10.1016/j.jcis.2024.05.091