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Circular RNA circHIPK2 inhibits colon cancer cells through miR-373-3p/RGMA axis.
- Source :
-
Cancer letters [Cancer Lett] 2024 Jul 01; Vol. 593, pp. 216957. Date of Electronic Publication: 2024 May 16. - Publication Year :
- 2024
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Abstract
- Circular RNAs (circRNAs) have been implicated in cancer development. However, their regulation, function, and underlying mechanisms of action remain unclear. We found that circHIPK2 was downregulated in colon cancer, and low expression levels of circHIPK2 were associated with high tumor grade and poor patient survival. The expression of circHIPK2 was observed to be regulated by the transcription factor HOXD10, which was downregulated in colon cancer. Consequently, low circHIPK2 expression promoted colon cancer cell proliferation, migration, and invasion in vitro and tumor growth and metastasis in vivo. Mechanistically, circHIPK2 sponges miR-373-3p to upregulate the expression of the tumor suppressor RGMA, leading to the activation of BMP/Smad signaling and, ultimately, the inhibition of colon cancer cells, indicating that circHIPK2 inhibits colon cancer cells through the miR-373-3p/RGMA/BMP pathway. These findings revealed a previously unknown regulation, function, and underlying mechanism of circHIPK2 in cancer cells. Hence, circHIPK2 may have a prognostic value and serve as a potential target for colon cancer treatment.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Female
Humans
Male
Mice
Carrier Proteins
Cell Line, Tumor
Cell Movement
Homeodomain Proteins genetics
Homeodomain Proteins metabolism
Intracellular Signaling Peptides and Proteins genetics
Intracellular Signaling Peptides and Proteins metabolism
Mice, Inbred BALB C
Mice, Nude
Nerve Tissue Proteins genetics
Nerve Tissue Proteins metabolism
Prognosis
Protein Serine-Threonine Kinases genetics
Protein Serine-Threonine Kinases metabolism
Signal Transduction
Transcription Factors genetics
Transcription Factors metabolism
Cell Proliferation
Colonic Neoplasms genetics
Colonic Neoplasms pathology
Colonic Neoplasms metabolism
Gene Expression Regulation, Neoplastic
MicroRNAs genetics
MicroRNAs metabolism
RNA, Circular genetics
RNA, Circular metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 593
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 38762192
- Full Text :
- https://doi.org/10.1016/j.canlet.2024.216957