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MicroRNAs in Helicobacter pylori-infected gastric cancer: Function and clinical application.
- Source :
-
Pharmacological research [Pharmacol Res] 2024 Jul; Vol. 205, pp. 107216. Date of Electronic Publication: 2024 May 16. - Publication Year :
- 2024
-
Abstract
- Gastric cancer (GC) is the leading cause of cancer-related death worldwide, and it is associated with a combination of genetic, environmental, and microbial risk factors. Helicobacter pylori (H. pylori) is classified as a type I carcinogen, however, the exact regulatory mechanisms underlying H. pylori-induced GC are incompletely defined. MicroRNAs (miRNAs), one of small non-coding RNAs, negatively regulate gene expression through binding to their target genes. Dysregulation of miRNAs is crucial in human cancer. A noteworthy quantity of aberrant miRNAs induced by H. pylori through complex regulatory networks have been identified. These miRNAs substantially affect genetic instability, cell proliferation, apoptosis, invasion, metastasis, autophagy, chemoresistance, and the tumor microenvironment, leading to GC development and progression. Importantly, some H. pylori-associated miRNAs hold promise as therapeutic tools and biomarkers for GC prevention, diagnosis, and prognosis. Nonetheless, clinical application of miRNAs remains in its infancy with multiple issues, including sensitivity and specificity, stability, reliable delivery systems, and off-target effects. Additional research on the specific molecular mechanisms and more clinical data are still required. This review investigated the biogenesis, regulatory mechanisms, and functions of miRNAs in H. pylori-induced GC, offering novel insights into the potential clinical applications of miRNA-based therapeutics and biomarkers.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Animals
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Gene Expression Regulation, Neoplastic
Stomach Neoplasms microbiology
Stomach Neoplasms genetics
MicroRNAs genetics
MicroRNAs metabolism
Helicobacter pylori genetics
Helicobacter Infections microbiology
Helicobacter Infections genetics
Helicobacter Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1186
- Volume :
- 205
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 38761883
- Full Text :
- https://doi.org/10.1016/j.phrs.2024.107216