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The cryptic metabolites and anti-phytopathogenic activities from Nigrospora lacticolonia and Penicillium rubens uncovered by the synergism with host Paris polyphylla, monoculture, and co-culture.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2024 Jul; Vol. 148, pp. 107438. Date of Electronic Publication: 2024 May 09. - Publication Year :
- 2024
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Abstract
- The synergism of host Paris polyphylla medium, the monoculture, and the coculture led to seventeen new metabolites, including eight sesquiterpenes, 1-7 having uncommon structural motifs compared to similar caryophyllene derivatives, 8 with an unprecedented bicyclic framework, and three xyloketals (13-15) with unprecedented frameworks from Nigrospora lacticolonia; one polyketide, 17 with novel bicyclo [2.2.2] undecane skeleton, and five polyketide-terpenoid hybrids, 20 (one novel sulfated), 21-24 from Penicillium rubens. The structures were determined mainly by the NMR, HRESIMS, ECD calculation, and single-crystal X-ray diffraction. Nine cryptic compounds (2-4, 5, 12-15, 17) were produced by the inductions of host medium and the coculture. The compounds 13 from N. lacticolonia, 24-26, 28, 29, and 31 from P. rubens indicated significant antiphytopathogenic activities against N. lacticolonia with MICs at 2-4 μg/mL. Moreover, compounds 22-26, 28, 29, and 31 from P. rubens showed antifungal activities against P. rubens with MICs at 2-4 μg/mL. The synergistic effects of host medium and the coculture can induce the structural diversity of metabolites.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Molecular Structure
Ascomycota drug effects
Ascomycota chemistry
Ascomycota metabolism
Structure-Activity Relationship
Antifungal Agents pharmacology
Antifungal Agents chemistry
Microbial Sensitivity Tests
Dose-Response Relationship, Drug
Penicillium chemistry
Penicillium metabolism
Penicillium drug effects
Coculture Techniques
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 148
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38761703
- Full Text :
- https://doi.org/10.1016/j.bioorg.2024.107438