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Stage-related increase in PIM2 expression in mycosis fungoides.
- Source :
-
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2024 Aug; Vol. 132 (8), pp. 564-570. Date of Electronic Publication: 2024 May 16. - Publication Year :
- 2024
-
Abstract
- The oncogene PIM2 is upregulated in several malignancies but has never been investigated in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). PIM2 is a well-known oncogene and is regulated by cell signaling pathways like the JAK/STAT- and NF-kB-pathway, key regulators in the pathogenesis of CTCL. The aim of this study was to examine the role of PIM2 in MF. PIM2 gene expression was measured in 81 formalin-fixed paraffin-embedded skin biopsies from patients with MF and 46 control biopsies from healthy skin (HS) and benign inflammatory skin disease (BID). Validation of PIM2 protein expression was performed on selected biopsies with immunohistochemical staining. We found a significant difference in gene expression levels between both early stage MF and HS (p < 0.0001), and BID (p < 0.0001). In addition, the PIM2 gene expression was higher in advanced-stage MF compared to early stage disease (p = 0.0001). No significant difference in gene expression levels was found between patients with and without disease progression. In conclusion, we found PIM2 expression is significantly increased in MF compared to controls, and in advanced-stage MF compared to early stage MF. These findings could potentially have diagnostic value in discriminating early stage MF from BID.<br /> (© 2024 Scandinavian Societies for Pathology, Medical Microbiology and Immunology.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Aged
Immunohistochemistry
Skin Neoplasms genetics
Skin Neoplasms pathology
Aged, 80 and over
Biopsy
Skin pathology
Skin metabolism
Young Adult
Mycosis Fungoides genetics
Mycosis Fungoides pathology
Mycosis Fungoides metabolism
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins metabolism
Protein Serine-Threonine Kinases genetics
Protein Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0463
- Volume :
- 132
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 38757234
- Full Text :
- https://doi.org/10.1111/apm.13423