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Current status of endoscopic ultrasound-guided antitumor treatment for pancreatic cancer.

Authors :
Matsumoto K
Kato H
Tsutsumi K
Otsuka M
Source :
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society [Dig Endosc] 2025 Jan; Vol. 37 (1), pp. 18-28. Date of Electronic Publication: 2024 May 16.
Publication Year :
2025

Abstract

Endoscopic ultrasound (EUS) was developed in the 1990s and has significantly transformed pancreatic tumor diagnosis. Subsequently, EUS has rapidly shifted from being a purely diagnostic procedure to being used in a wide range of interventional procedures. Recently, new therapeutic techniques, such as EUS-guided fine needle injection (EUS-FNI) or radiofrequency ablation (RFA), have been developed to deliver various antitumor agents. Despite technological advancements, pancreatic cancer (PC) has a poor prognosis and improvements in treatment outcomes are urgently required. One of the reasons for the limited response to antitumor agents in PC is the abundant desmoplasia and hypovascular nature of the tumor, complicating drug delivery into the tumor. Thus, changing the tumor microenvironment may be important to enhance the effectiveness of chemotherapy, and direct injection of antitumor agents into the tumor under EUS guidance can help overcome treatment challenges in PC. Treatment approaches using the EUS-FNI or RFA technique are expected to further improve the prognosis of PC. Therefore, this study reviewed the existing literature on EUS-guided antitumor therapy, specifically highlighting its application in PC to address the current challenges and to identify potential advancements in the field.<br /> (© 2024 The Authors. Digestive Endoscopy published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society.)

Details

Language :
English
ISSN :
1443-1661
Volume :
37
Issue :
1
Database :
MEDLINE
Journal :
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Publication Type :
Academic Journal
Accession number :
38752622
Full Text :
https://doi.org/10.1111/den.14815