A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017.

Authors :: Awano Y
Ishii R
Takahashi Y
Tsutsumi H
Watanabe Y
Sonoda M
Hokari R
Iwatsuki M
Inahashi Y
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 2024 Aug; Vol. 77 (8), pp. 540-543. Date of Electronic Publication: 2024 May 15.
Publication Year :: 2024
Abstract: A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.<br /> (© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)

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