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T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle.
- Source :
-
EBioMedicine [EBioMedicine] 2024 Jun; Vol. 104, pp. 105154. Date of Electronic Publication: 2024 May 14. - Publication Year :
- 2024
-
Abstract
- Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells. T cell exhaustion, characterized by diminished effector function, increased expression of co-inhibitory receptors, and clonal deletion, emerges as a hypofunctional state resulting from chronic exposure to antigens, posing an obstacle to ICB therapy. Several studies have deeply explored T cell exhaustion, providing innovative insights and correlating T cell exhaustion with tertiary lymphoid structures (TLS) formation. TLS, lymphocyte aggregates formed in non-lymphoid tissues amid chronic inflammation, serve as pivotal reservoirs for anti-tumour immunity. Here, we underscore the pivotal role of T cell exhaustion as a signalling mechanism in reinvigorating anti-tumour immunity by turbocharging cancer-immunity (CI) cycle, particularly when tumour becomes unmanageable. Building upon this concept, we summarize emerging immunotherapeutic strategies aimed at enhancing the response rate to ICB therapy and improving patient prognosis.<br />Competing Interests: Declaration of interests The authors declare that they have no competing interest.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Animals
Tumor Microenvironment immunology
Immunotherapy methods
Immune Checkpoint Inhibitors therapeutic use
Immune Checkpoint Inhibitors pharmacology
Signal Transduction
Disease Susceptibility
T-Cell Exhaustion
Tertiary Lymphoid Structures immunology
Tertiary Lymphoid Structures pathology
Neoplasms immunology
Neoplasms pathology
Neoplasms therapy
Neoplasms metabolism
T-Lymphocytes immunology
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2352-3964
- Volume :
- 104
- Database :
- MEDLINE
- Journal :
- EBioMedicine
- Publication Type :
- Academic Journal
- Accession number :
- 38749300
- Full Text :
- https://doi.org/10.1016/j.ebiom.2024.105154