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Fusion-harboring mast cells can explain molecular positivity in flow cytometric MRD-negative core-binding factor AML.
- Source :
-
Blood [Blood] 2024 Aug 01; Vol. 144 (5), pp. 581-585. - Publication Year :
- 2024
-
Abstract
- Abstract: Molecular measurable residual disease can persist in core-binding factor acute myeloid leukemia in otherwise disease-free patients. Utilizing cell sorting followed by fluorescent in situ hybridization, we show that detection is due to mast cells.<br /> (© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
- Subjects :
- Humans
In Situ Hybridization, Fluorescence
RUNX1 Translocation Partner 1 Protein genetics
RUNX1 Translocation Partner 1 Protein metabolism
Male
Core Binding Factor Alpha 2 Subunit genetics
Core Binding Factor Alpha 2 Subunit metabolism
Female
Mast Cells metabolism
Mast Cells pathology
Leukemia, Myeloid, Acute pathology
Leukemia, Myeloid, Acute genetics
Leukemia, Myeloid, Acute metabolism
Leukemia, Myeloid, Acute diagnosis
Flow Cytometry methods
Neoplasm, Residual diagnosis
Oncogene Proteins, Fusion genetics
Oncogene Proteins, Fusion metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 144
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 38749014
- Full Text :
- https://doi.org/10.1182/blood.2024024264