Back to Search
Start Over
Molecular beacon-based detection of circulating microRNA-containing extracellular vesicle as an α-synucleinopathy biomarker.
- Source :
-
Science advances [Sci Adv] 2024 May 17; Vol. 10 (20), pp. eadl6442. Date of Electronic Publication: 2024 May 15. - Publication Year :
- 2024
-
Abstract
- Early and precise diagnosis of α-synucleinopathies is challenging but critical. In this study, we developed a molecular beacon-based assay to evaluate microRNA-containing extracellular vesicles (EVs) in plasma. We recruited 1203 participants including healthy controls (HCs) and patients with isolated REM sleep behavior disorder (iRBD), α-synucleinopathies, or non-α-synucleinopathies from eight centers across China. Plasma miR-44438-containing EV levels were significantly increased in α-synucleinopathies, including those in the prodromal stage (e.g., iRBD), compared to both non-α-synucleinopathy patients and HCs. However, there are no significant differences between Parkinson's disease (PD) and multiple system atrophy. The miR-44438-containing EV levels negatively correlated with age and the Hoehn and Yahr stage of PD patients, suggesting a potential association with disease progression. Furthermore, a longitudinal analysis over 16.3 months demonstrated a significant decline in miR-44438-containing EV levels in patients with PD. These results highlight the potential of plasma miR-44438-containing EV as a biomarker for early detection and progress monitoring of α-synucleinopathies.
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
alpha-Synuclein blood
Case-Control Studies
MicroRNAs blood
Multiple System Atrophy blood
Multiple System Atrophy diagnosis
Extracellular Vesicles metabolism
Biomarkers blood
Circulating MicroRNA blood
Parkinson Disease blood
Parkinson Disease diagnosis
Synucleinopathies blood
Synucleinopathies diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2375-2548
- Volume :
- 10
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Science advances
- Publication Type :
- Academic Journal
- Accession number :
- 38748787
- Full Text :
- https://doi.org/10.1126/sciadv.adl6442