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A step-by-step guide to fragmenting bundled actin filaments.

Authors :
Kadzik RS
Kovar DR
Source :
The Journal of cell biology [J Cell Biol] 2024 Jun 03; Vol. 223 (6). Date of Electronic Publication: 2024 May 15.
Publication Year :
2024

Abstract

There has long been conflicting evidence as to how bundled actin filaments, found in cellular structures such as filopodia, are disassembled. In this issue, Chikireddy et al. (https://doi.org/10.1083/jcb.202312106) provide a detailed in vitro analysis of the steps involved in fragmentation of fascin-bundled actin filaments and propose a novel mechanism for severing two-filament bundles.<br /> (© 2024 Kadzik and Kovar.)

Details

Language :
English
ISSN :
1540-8140
Volume :
223
Issue :
6
Database :
MEDLINE
Journal :
The Journal of cell biology
Publication Type :
Academic Journal
Accession number :
38748453
Full Text :
https://doi.org/10.1083/jcb.202403191