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MLKL, a new actor of UVB-induced apoptosis in human diploid dermal fibroblasts.
- Source :
-
Cell death discovery [Cell Death Discov] 2024 May 14; Vol. 10 (1), pp. 232. Date of Electronic Publication: 2024 May 14. - Publication Year :
- 2024
-
Abstract
- Ultraviolet radiation (UVR) is a major environmental mutagen. In skin, UVR can initiate cancer through the induction of mutagenic DNA damage and promote its progression. An important cancer prevention mechanism is the regulated cell death (RCD), which can safely dispose of damaged cells. Apoptosis, a well-known RCD, is known to be activated by UVR, but part of the mechanism and proteins involved in UVR-induced apoptosis are still to be discovered. Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) are two proteins involved in necroptosis, a form of RCD. Here, we have evaluated the implication of RIPK3 and MLKL in UVB-induced cell death in human diploid dermal fibroblasts. Our results show that RIPK3 and MLKL play opposite roles in UVB-induced cell death, in a necroptosis independent pathway. We showed that RIPK3 protects cells from UVB cell death, while MLKL sensitizes cells to UVB-induced apoptosis. Taken together these results are the first to show the implication of RIPK3 and MLKL in survival and apoptosis, respectively, bringing two new actors in UVB-induced cell death pathway.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2058-7716
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell death discovery
- Publication Type :
- Academic Journal
- Accession number :
- 38744823
- Full Text :
- https://doi.org/10.1038/s41420-024-02004-4