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Six new diterpenoids with anti-inflammatory and cytotoxic activity from Isodon serra.
- Source :
-
Fitoterapia [Fitoterapia] 2024 Jul; Vol. 176, pp. 106019. Date of Electronic Publication: 2024 May 12. - Publication Year :
- 2024
-
Abstract
- Diterpenoids occupy an important slot of the natural products diversity space with wide ranges of bioactivities and complex structures, providing potential applications for the development of therapeutics. In this study, we reported four new abietane-type diterpenoids viroxocin B-E (1-4), a new totarane-type diterpenoid viroxocin F (5), and a new sempervirane-type diterpenoid viroxocin G (6) along with four known compounds (7-10), isolated and identified from a widely used Traditional Chinese Medicine, Isodon serra (I. serra). Their structures were established by spectroscopic data analysis, experimental and calculated electronic circular dichroism (ECD) data, as well as X-ray diffraction analysis. Compounds 2, 5, 7, 8 and 10 exhibited promising anti-inflammatory activities in lipopolysaccharide (LPS)-induced RAW 267.4 cells, and their inhibition rates on NO production were more than 60% at 10 μM. Compound 7 showed cytotoxicity against human renal cell carcinoma 769P at 20 μM, the inhibition rate was 52.66%.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interest.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Molecular Structure
Mice
Animals
Cell Line, Tumor
China
RAW 264.7 Cells
Nitric Oxide metabolism
Diterpenes pharmacology
Diterpenes isolation & purification
Diterpenes chemistry
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents isolation & purification
Isodon chemistry
Antineoplastic Agents, Phytogenic pharmacology
Antineoplastic Agents, Phytogenic isolation & purification
Phytochemicals pharmacology
Phytochemicals isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 176
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 38744380
- Full Text :
- https://doi.org/10.1016/j.fitote.2024.106019