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Cichorium glandulosum Ameliorates HFD-Induced Obesity in Mice by Modulating Gut Microbiota and Bile Acids.
- Source :
-
Journal of medicinal food [J Med Food] 2024 Jul; Vol. 27 (7), pp. 601-614. Date of Electronic Publication: 2024 May 14. - Publication Year :
- 2024
-
Abstract
- Obesity is an ongoing global health problem, and Cichorium glandulosum (CG, chicory) is traditionally used as a hepatoprotective and lipid-lowering drug. However, there is still a lack of research on the role of CG in the treatment of obesity. In the present study, we found that CG significantly delayed weight gain and positively affected glucolipid metabolism disorders, serum metabolism levels, and the degree of liver and kidney oxidative stress in high-fat diet (HFD) mice. Further examination of the effects of CG on intestinal microenvironmental dysregulation and its metabolites in HFD mice revealed that the CG ethanol extract high-dose group (CGH) did not have a significant regulatory effect on short-chain fatty acids. Still, CGH significantly decreased the levels of 12α-OH/non-12α-OH bile acids and also found significant upregulation of proteobacteria and downregulation of cyanobacteria at the phylum level. CG may have ameliorated obesity and metabolic abnormalities in mice by repairing gut microbiota dysbiosis and modulating bile acid biosynthesis.
- Subjects :
- Animals
Mice
Male
Humans
Cichorium intybus chemistry
Liver metabolism
Liver drug effects
Bacteria classification
Bacteria isolation & purification
Bacteria drug effects
Bacteria genetics
Bacteria metabolism
Dysbiosis drug therapy
Oxidative Stress drug effects
Gastrointestinal Microbiome drug effects
Obesity metabolism
Obesity drug therapy
Diet, High-Fat adverse effects
Bile Acids and Salts metabolism
Mice, Inbred C57BL
Plant Extracts pharmacology
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7600
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of medicinal food
- Publication Type :
- Academic Journal
- Accession number :
- 38742981
- Full Text :
- https://doi.org/10.1089/jmf.2024.k.0030