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Nebulized Inhalation of Peptide-Modified DNA Origami To Alleviate Acute Lung Injury.
- Source :
-
Nano letters [Nano Lett] 2024 May 22; Vol. 24 (20), pp. 6102-6111. Date of Electronic Publication: 2024 May 13. - Publication Year :
- 2024
-
Abstract
- Acute lung injury (ALI) is a severe inflammatory lung disease, with high mortality rates. Early intervention by reactive oxygen species (ROS) scavengers could reduce ROS accumulation, break the inflammation expansion chain in alveolar macrophages (AMs), and avoid irreversible damage to alveolar epithelial and endothelial cells. Here, we reported cell-penetrating R9 peptide-modified triangular DNA origami nanostructures (tDONs-R9) as a novel nebulizable drug that could reach the deep alveolar regions and exhibit an enhanced uptake preference of macrophages. tDONs-R9 suppressed the expression of pro-inflammatory cytokines and drove polarization toward the anti-inflammatory M2 phenotype in macrophages. In the LPS-induced ALI mouse model, treatment with nebulized tDONs-R9 alleviated the overwhelming ROS, pro-inflammatory cytokines, and neutrophil infiltration in the lungs. Our study demonstrates that tDONs-R9 has the potential for ALI treatment, and the programmable DNA origami nanostructures provide a new drug delivery platform for pulmonary disease treatment with high delivery efficiency and biosecurity.
- Subjects :
- Animals
Mice
Administration, Inhalation
Reactive Oxygen Species metabolism
Macrophages, Alveolar drug effects
Macrophages, Alveolar metabolism
Cytokines metabolism
Peptides chemistry
Nebulizers and Vaporizers
Cell-Penetrating Peptides chemistry
Disease Models, Animal
Lipopolysaccharides
Drug Delivery Systems
RAW 264.7 Cells
Acute Lung Injury drug therapy
Acute Lung Injury pathology
Acute Lung Injury chemically induced
DNA chemistry
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 24
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 38739578
- Full Text :
- https://doi.org/10.1021/acs.nanolett.4c01222