Back to Search
Start Over
Diseases associated with multiple sclerosis and epilepsy. A population cohort study of 159,200 middle-aged, urban, native Swedes observed over 10 years (1970-79).
- Source :
-
Acta neurologica Scandinavica [Acta Neurol Scand] 1985 Apr; Vol. 71 (4), pp. 267-77. - Publication Year :
- 1985
-
Abstract
- A defined general population of 159,200 male and female native Swedes born in the period 1911-1940 from an urban catchment area of the then only general hospital, was followed over a decade (1970-79) with regard to in-patient hospitalization for all kinds of diagnoses. As a part of this population cohort study, multiple sclerosis cases (n = 351) and epilepsy cases (n = 648) were studied for association with other diseases. Unexpectedly, a cluster of diseases encompassing tuberculosis, bronchial asthma, diabetes mellitus and myocardial infarction, among the diseases associated with multiple sclerosis, also forms a gradient; this suggests a quantitative rather than a qualitative multifactorial model of disease for the understanding of the pathogenesis of MS. In epilepsy, heterogeneity was suggested as being mainly linked to the presence or absence of co-existing alcoholism. Brain tumours in cases of epilepsy were found almost exclusively in the latter subset and prevailing among younger people independent of sex (with an almost 100-fold excess rate of that disease combination as expected by chance only).
- Subjects :
- Aged
Alcoholism mortality
Asthma mortality
Brain Damage, Chronic mortality
Brain Neoplasms mortality
Cross-Sectional Studies
Diabetes Mellitus mortality
Female
Humans
Male
Middle Aged
Myocardial Infarction mortality
Sweden
Tuberculosis, Pulmonary mortality
Virus Diseases mortality
Epilepsy mortality
Multiple Sclerosis mortality
Urban Population
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6314
- Volume :
- 71
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta neurologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 3873780