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Cryopreservation of ovarian tissue for fertility preservation in breast cancer patients: time to stop?

Authors :
Macklon KT
De Vos M
Source :
Reproductive biomedicine online [Reprod Biomed Online] 2024 Jul; Vol. 49 (1), pp. 103939. Date of Electronic Publication: 2024 Mar 08.
Publication Year :
2024

Abstract

Fertility preservation is currently offered to young women with breast cancer to increase their chances of motherhood after a potentially gonadotoxic treatment. Ovarian stimulation with oocyte vitrification and cryopreservation of ovarian tissue remain the most commonly used methods of choice. Whichever method is preferred is very much dependent on the practice and experience of the clinics, although for breast cancer in particular one method might be superior to the other. Cryopreservation of ovarian tissue is inevitably associated with the iatrogenic reduction of the ovarian reserve of a patient and should only be offered to women with a high risk of premature ovarian insufficiency following treatment. However, for younger breast cancer survivors, pregnancy and delivery rates are reassuringly high, even after chemotherapy. Despite its widespread use, few women come back to make use of their cryopreserved tissue. It is argued here that cryopreservation of ovarian tissue is not an appropriate option for breast cancer patients and discuss the reasons for this opinion.<br /> (Copyright © 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1472-6491
Volume :
49
Issue :
1
Database :
MEDLINE
Journal :
Reproductive biomedicine online
Publication Type :
Academic Journal
Accession number :
38733675
Full Text :
https://doi.org/10.1016/j.rbmo.2024.103939