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Treatment strategy for HER2-negative advanced gastric cancer: salvage-line strategy for advanced gastric cancer.
- Source :
-
International journal of clinical oncology [Int J Clin Oncol] 2024 Sep; Vol. 29 (9), pp. 1237-1243. Date of Electronic Publication: 2024 May 11. - Publication Year :
- 2024
-
Abstract
- After immune checkpoint inhibitor (ICI) comes into third-line treatment of advanced gastric cancer, the therapeutic strategy has been dramatically changed. Recent first-line regimen, which consists of ICI and chemotherapeutic agents, prolonged progression-free survival, and subsequent treatment options enabled continuous treatment beyond second-line therapy. Moreover, the advent of vascular endothelial growth factor (VEGF)-targeted agents including angiogenesis inhibitors and TKIs provides an opportunity of considering the interaction between ICI and anti-VEGF agents, and facilitating novel treatment proposal. Although clinical benefit of prolonged VEGF blockade after disease progression has not been confirmed in gastric cancer, combination therapy of cytotoxic agents and anti-VEGF agent, such as irinotecan plus ramucirumab demonstrated favorable objective response rate and progression-free survival in third- or later-line setting. In this review, we discuss recent progress and future directions of later-line treatments of HER2-negative advancer gastric cancer.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Immune Checkpoint Inhibitors therapeutic use
Ramucirumab
Angiogenesis Inhibitors therapeutic use
Progression-Free Survival
Vascular Endothelial Growth Factor A antagonists & inhibitors
Vascular Endothelial Growth Factor A metabolism
Stomach Neoplasms drug therapy
Stomach Neoplasms pathology
Receptor, ErbB-2
Salvage Therapy methods
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7772
- Volume :
- 29
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38733489
- Full Text :
- https://doi.org/10.1007/s10147-024-02500-8