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Longitudinal study on salivary IL-6 trajectories in postoperative OSCC patients after chemotherapy and radiotherapy.
- Source :
-
Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2024 Sep; Vol. 125 (4S), pp. 101909. Date of Electronic Publication: 2024 May 08. - Publication Year :
- 2024
-
Abstract
- Background: Oral squamous cell carcinoma (OSCC) poses a significant healthcare challenge globally, necessitating precise biomarkers for effective management. Interleukin-6 (IL-6) in saliva has emerged as a potential biomarker, yet its dynamics post-chemotherapy and radiotherapy remain underexplored.<br />Aim: The aim of our study is to investigate the longitudinal dynamics of salivary interleukin-6 (IL-6) expression in postoperative OSCC patients over a one-year follow-up period after chemotherapy and radiotherapy.<br />Methods: This longitudinal study enrolled 60 participants, including postoperative OSCC patients and controls, collecting saliva samples over one year. RT-PCR and ELISA techniques measured IL-6 expression. Statistical analyses, including repeated measures ANOVA and univariate tests, evaluated IL-6 dynamics.<br />Results: Pre-treatment, OSCC patients exhibited elevated IL-6 levels compared to controls. Post-therapy, IL-6 levels decreased significantly with p < .0001, indicating treatment response and further result to baseline normalizing at 6-month follow-up. Significant differences were observed across treatment stages, supporting IL-6 as a diagnostic and prognostic marker for OSCC. RT-PCR and ELISA results showed the statistical significance of IL-6's role as a predictive marker.<br />Conclusion: Salivary IL-6 emerges as a promising biomarker in OSCC management, necessitating further research to harness its diagnostic and therapeutic potential. By understanding IL-6 dynamics, personalized treatment approaches can be developed to improve patient outcomes. Longitudinal studies with larger cohorts and multi-omics approaches are warranted to validate findings and identify novel therapeutic targets.<br />Competing Interests: Declaration of competing interest There is no conflict of interest among authors.<br /> (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Humans
Longitudinal Studies
Male
Female
Middle Aged
Aged
Adult
Biomarkers, Tumor metabolism
Biomarkers, Tumor analysis
Enzyme-Linked Immunosorbent Assay
Interleukin-6 analysis
Interleukin-6 metabolism
Saliva chemistry
Saliva metabolism
Carcinoma, Squamous Cell therapy
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell diagnosis
Mouth Neoplasms therapy
Mouth Neoplasms metabolism
Mouth Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2468-7855
- Volume :
- 125
- Issue :
- 4S
- Database :
- MEDLINE
- Journal :
- Journal of stomatology, oral and maxillofacial surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38729427
- Full Text :
- https://doi.org/10.1016/j.jormas.2024.101909