Characteristic cembrane-type diterpenoids with nitric oxide inhibitory activity from the gum resin of Boswellia carterii Birdw.

Authors :: Xu LL
Chen ZC
He ML
Fu JJ
Li Y
Luo YM
Chen FY
Source :: Fitoterapia [Fitoterapia] 2024 Jul; Vol. 176, pp. 106000. Date of Electronic Publication: 2024 May 08.
Publication Year :: 2024
Abstract: Five new characteristic cembrane-type diterpenoids (olibacartiols A-E, 1-5) were acquired from the gum resin of Boswellia carterii. The structures of these diterpenoids were characterized by detailed spectroscopic analysis, and compounds 1-3 were unambiguously confirmed by single-crystal X-ray diffraction experiments. The anti-inflammatory activities of the isolated compounds were evaluated using LPS-induced BV2 cell model and compounds 2-5 showed moderate NO inhibitory effects with IC <subscript>50</subscript> values of 8.84 ± 1.02, 9.82 ± 1.95, 9.75 ± 2.24, and 7.39 ± 1.24 μM, respectively.<br />Competing Interests: Declaration of competing interest The authors declare no compete in financial interests.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Subjects :: Molecular Structure
Animals
Mice
Cell Line
China
Plant Gums chemistry
Plant Gums pharmacology
Diterpenes pharmacology
Diterpenes isolation & purification
Diterpenes chemistry
Boswellia chemistry
Nitric Oxide metabolism
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents chemistry
Resins, Plant chemistry
Phytochemicals pharmacology
Phytochemicals isolation & purification

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