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4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling.
- Source :
-
Aging [Aging (Albany NY)] 2024 May 08; Vol. 16 (9), pp. 8142-8154. Date of Electronic Publication: 2024 May 08. - Publication Year :
- 2024
-
Abstract
- The specific mechanism of 4-hydroxysesamin (4-HS), a modification of Sesamin, on right ventricular failure due to pulmonary hypertension (PH) is ominous. By creating a rat model of PH in vivo and a model of pulmonary artery smooth muscle cell (PASMC) hypoxia and inflammation in vitro , the current work aimed to investigate in depth the molecular mechanism of the protective effect of 4-HS. In an in vitro model of hypoxia PASMC, changes in cell proliferation and inflammatory factors were detected after treatment with 4-HS, followed by changes in the JNK/p38 MAPK signaling pathway as detected by Western blot signaling pathway. The findings demonstrated that 4-HS was able to minimize PASMC cell death, block the JNK/p38 MAPK signaling pathway, and resist the promoting effect of hypoxia on PASMC cell proliferation. Following that, we found that 4-HS could both mitigate the right ventricular damage brought on by MCT and had a protective impact on rats Monocrotaline (MCT)-induced PH in in vivo investigations. The key finding of this study is that 4-HS may protect against PH by inhibiting the JNK/p38 MAPK signaling pathway.
- Subjects :
- Animals
Rats
Male
Ventricular Dysfunction, Right metabolism
Myocytes, Smooth Muscle drug effects
Myocytes, Smooth Muscle metabolism
Lignans pharmacology
Lignans therapeutic use
Pulmonary Artery drug effects
Pulmonary Artery pathology
Pulmonary Artery metabolism
Heart Failure metabolism
Rats, Sprague-Dawley
Monocrotaline
Disease Models, Animal
Hypertension, Pulmonary metabolism
Hypertension, Pulmonary drug therapy
p38 Mitogen-Activated Protein Kinases metabolism
MAP Kinase Signaling System drug effects
Cell Proliferation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 38728253
- Full Text :
- https://doi.org/10.18632/aging.205808