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Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice.
- Source :
-
Neurochemical research [Neurochem Res] 2024 Jul; Vol. 49 (7), pp. 1838-1850. Date of Electronic Publication: 2024 May 10. - Publication Year :
- 2024
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Abstract
- Menaquinone-4 (MK-4) is an isoform of vitamin K <subscript>2</subscript> that has been shown to exert various biological actions besides its functions in blood coagulation and bone metabolism. Here we examined the effect of MK-4 on a mouse model of intracerebral hemorrhage (ICH). Daily oral administration of 200 mg/kg MK-4 starting from 3 h after induction of ICH by intrastriatal collagenase injection significantly ameliorated neurological deficits. Unexpectedly, MK-4 produced no significant effects on various histopathological parameters, including the decrease of remaining neurons and the increase of infiltrating neutrophils within the hematoma, the increased accumulation of activated microglia/macrophages and astrocytes around the hematoma, as well as the injury volume and brain swelling by hematoma formation. In addition, ICH-induced increases in nitrosative/oxidative stress reflected by changes in the immunoreactivities against nitrotyrosine and heme oxygenase-1 as well as the contents of malondialdehyde and glutathione were not significantly affected by MK-4. In contrast, MK-4 alleviated axon tract injury in the internal capsule as revealed by neurofilament-H immunofluorescence. Enhanced preservation of the corticospinal tract by MK-4 was also confirmed by retrograde labeling of neurons in the primary motor cortex innervating the spinal cord. These results suggest that MK-4 produces therapeutic effect on ICH by protecting structural integrity of the corticospinal tract.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Animals
Male
Mice
Mice, Inbred C57BL
Oxidative Stress drug effects
Neuroprotective Agents therapeutic use
Neuroprotective Agents pharmacology
Nervous System Diseases etiology
Nervous System Diseases drug therapy
Cerebral Hemorrhage drug therapy
Cerebral Hemorrhage metabolism
Vitamin K 2 analogs & derivatives
Vitamin K 2 pharmacology
Vitamin K 2 therapeutic use
Pyramidal Tracts drug effects
Pyramidal Tracts metabolism
Pyramidal Tracts pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6903
- Volume :
- 49
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 38727984
- Full Text :
- https://doi.org/10.1007/s11064-024-04150-8