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Systemic correlates of cutaneous manifestations of lupus erythematosus.
- Source :
-
International journal of dermatology [Int J Dermatol] 2024 Aug; Vol. 63 (8), pp. e148-e156. Date of Electronic Publication: 2024 May 10. - Publication Year :
- 2024
-
Abstract
- Background: We aimed to investigate the prevalence of skin disease among patients with systemic lupus erythematosus (SLE) and determine whether LE skin disease had clinical or serologic correlates with SLE.<br />Methods: We reviewed records of 335 patients with SLE (seen at Mayo Clinic, Rochester, Minnesota, USA) and abstracted skin manifestations, fulfilled mucocutaneous SLE criteria, and clinical and serologic parameters.<br />Results: Of the 231 patients with skin manifestations, 57 (24.7%) had LE-specific conditions, 102 (44.2%) had LE-nonspecific conditions, and 72 (31.2%) had both. LE skin disease was associated with photosensitivity, anti-Smith antibodies, and anti-U1RNP antibodies (all P < 0.001). Patients without LE skin disease more commonly had elevated C-reactive protein levels (P = 0.01). Patients meeting 2-4 mucocutaneous American College of Rheumatology criteria less commonly had cytopenia (P = 0.004) or anti-double-stranded DNA antibodies (P = 0.004). No significant associations were observed for systemic involvement (renal, hematologic, neurologic, and arthritis) when comparing patients with or without LE skin involvement. LE skin involvement was not significantly associated with internal SLE disease flare, number of medications, or overall survival.<br />Conclusions: LE skin disease commonly occurs in patients with SLE. The presence of LE skin disease had no mitigating impact on the severity of SLE sequelae, disease flares, number of medications, or overall survival.<br /> (© 2024 Mayo Foundation for Medical Education and Research. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
- Subjects :
- Humans
Female
Male
Adult
Middle Aged
Retrospective Studies
C-Reactive Protein analysis
Prevalence
Young Adult
Severity of Illness Index
Aged
Ribonucleoprotein, U1 Small Nuclear immunology
Lupus Erythematosus, Systemic complications
Lupus Erythematosus, Systemic immunology
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic epidemiology
Lupus Erythematosus, Cutaneous immunology
Lupus Erythematosus, Cutaneous blood
Lupus Erythematosus, Cutaneous epidemiology
Lupus Erythematosus, Cutaneous complications
Photosensitivity Disorders etiology
Photosensitivity Disorders epidemiology
Photosensitivity Disorders blood
Photosensitivity Disorders immunology
Antibodies, Antinuclear blood
Antibodies, Antinuclear immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-4632
- Volume :
- 63
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 38727096
- Full Text :
- https://doi.org/10.1111/ijd.17178