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Understanding the biology of monkeypox virus to prevent future outbreaks.
- Source :
-
Nature microbiology [Nat Microbiol] 2024 Jun; Vol. 9 (6), pp. 1408-1416. Date of Electronic Publication: 2024 May 09. - Publication Year :
- 2024
-
Abstract
- Historically, monkeypox (mpox) was a zoonotic disease endemic in Africa. However, in 2022, a global outbreak occurred following a substantial increase in cases in Africa, coupled with spread by international travellers to other continents. Between January 2022 and October 2023, about 91,000 confirmed cases from 115 countries were reported, leading the World Health Organization to declare a public health emergency. The basic biology of monkeypox virus (MPXV) can be inferred from other poxviruses, such as vaccinia virus, and confirmed by genome sequencing. Here the biology of MPXV is reviewed, together with a discussion of adaptive changes during MPXV evolution and implications for transmission. Studying MPXV biology is important to inform specific host interactions, to aid in ongoing outbreaks and to predict those in the future.<br /> (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
- Subjects :
- Humans
Animals
Zoonoses virology
Zoonoses epidemiology
Zoonoses transmission
Zoonoses prevention & control
Genome, Viral
Africa epidemiology
Phylogeny
Monkeypox virus genetics
Monkeypox virus physiology
Monkeypox virus pathogenicity
Mpox (monkeypox) epidemiology
Mpox (monkeypox) transmission
Mpox (monkeypox) virology
Mpox (monkeypox) prevention & control
Disease Outbreaks prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2058-5276
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38724757
- Full Text :
- https://doi.org/10.1038/s41564-024-01690-1