Back to Search
Start Over
Electrophoretic mobility of erythrocytes exposed to accelerated helium nuclei or to gamma-rays, as modified by adeturone.
- Source :
-
International journal of radiation biology and related studies in physics, chemistry, and medicine [Int J Radiat Biol Relat Stud Phys Chem Med] 1985 Mar; Vol. 47 (3), pp. 285-90. - Publication Year :
- 1985
-
Abstract
- The electrophoretic mobility of human erythrocytes exposed in whole blood or in cell suspensions to relatively low doses (0.7-2.5 Gy) of accelerated helium nuclei (4.6 GeV/nucleon) or of gamma-rays was found to diminish with increase in radiation dose, as measured at 3 h post-irradiation. Pre-treatment with a radioprotectant, adeturone (S-2-aminoethylisothiuronium adenosine-5'-triphosphate), allowed electrophoretic mobility to be maintained within normal limits, with more stable values in the case of alpha-irradiations. The experimental evidence is discussed in terms of the protectant's involvement in repair of radiation-induced conformational changes in surface membrane components.
- Subjects :
- Adenosine Triphosphate pharmacology
Alpha Particles
Cesium Radioisotopes
Electrophoresis
Erythrocytes drug effects
Gamma Rays
Humans
In Vitro Techniques
beta-Aminoethyl Isothiourea pharmacology
Adenosine Triphosphate analogs & derivatives
Erythrocytes radiation effects
Radiation-Protective Agents pharmacology
beta-Aminoethyl Isothiourea analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7616
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology and related studies in physics, chemistry, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3872281
- Full Text :
- https://doi.org/10.1080/09553008514550421