Back to Search
Start Over
Prevalence of Musculoskeletal and Metabolic Disorders in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2024 Apr 24; Vol. 37, pp. 12312. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Introduction: Musculoskeletal disorders could be associated with metabolic disorders that are common after kidney transplantation, which could reduce the quality of life of patients. The aim of this study was to assess the prevalence of both musculoskeletal and metabolic disorders in kidney transplant patients.<br />Methods: MEDLINE, CINAHL, Cochrane Library, EMBASE and Web of Science were searched from their inception up to June 2023. DerSimonian and Laird random-effects method was used to calculate pooled prevalence estimates and their 95% confidence intervals (CIs).<br />Results: 21,879 kidney transplant recipients from 38 studies were analysed. The overall proportion of kidney transplant patients with musculoskeletal disorders was 27.2% (95% CI: 18.4-36.0), with low muscle strength (64.5%; 95% CI: 43.1-81.3) being the most common disorder. Otherwise, the overall proportion of kidney transplant patients with metabolic disorders was 37.6% (95% CI: 21.9-53.2), with hypovitaminosis D (81.8%; 95% CI: 67.2-90.8) being the most prevalent disorder.<br />Conclusion: The most common musculoskeletal disorders were low muscle strength, femoral osteopenia, and low muscle mass. Hypovitaminosis D, hyperparathyroidism, and hyperuricemia were also the most common metabolic disorders. These disorders could be associated with poorer quality of life in kidney transplant recipients.<br />Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier [CRD42023449171].<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Herreros-Carretero, Berlanga-Macías, Martínez-Vizcaíno, Torres-Costoso, Pascual-Morena, Hernández-Castillejo, Sequí-Domínguez and Garrido-Miguel.)
- Subjects :
- Humans
Prevalence
Quality of Life
Muscle Strength
Transplant Recipients
Vitamin D Deficiency epidemiology
Vitamin D Deficiency complications
Bone Diseases, Metabolic epidemiology
Bone Diseases, Metabolic etiology
Postoperative Complications epidemiology
Postoperative Complications etiology
Kidney Transplantation adverse effects
Musculoskeletal Diseases epidemiology
Musculoskeletal Diseases etiology
Metabolic Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 37
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 38720821
- Full Text :
- https://doi.org/10.3389/ti.2024.12312