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Hepatic T1-time, cardiac structure and function and cardiovascular outcomes in patients with dilated cardiomyopathy.
- Source :
-
European journal of internal medicine [Eur J Intern Med] 2024 Sep; Vol. 127, pp. 84-90. Date of Electronic Publication: 2024 May 07. - Publication Year :
- 2024
-
Abstract
- Aim: Liver damage frequently occurs in patients with cardiovascular (CV) disease and is associated with adverse clinical outcomes. The associations of liver damage with cardiac structure/function measures and the risk of adverse CV events in patients with dilated cardiomyopathy (DCM) are poorly known.<br />Methods: We retrospectively enrolled consecutive patients with DCM undergoing cardiac magnetic resonance imaging (MRI). In addition to standard cardiac assessment, iron-corrected T1 mapping was also assessed in the liver. Cross-sectional associations between hepatic T1-time and cardiac structure and function were examined accounting for potential confounders. Longitudinal associations between hepatic T1-time and the risk of hospitalization for HF or CV death were also assessed.<br />Results: Overall, 120 stable patients with established DCM were included in the study (mean age 54.7 years, 26 % women). The mean hepatic iron-corrected T1-time was 563±73 ms. In linear regression analyses, measures of left atrial structure (LA maximal volume, p = 0.035, LA minimal volume=0.012), interventricular septum thickness (p = 0.026), and right ventricular ejection fraction (p = 0.005) were significantly associated with greater hepatic T1-time. Over a mean follow-up of 4.5 ± 1.8 years, 32 (27 %) died or were hospitalized for HF at a rate of 6.7 per 100 person-year. Higher hepatic iron-corrected T1-time was independently associated with a higher risk of adverse events (adjusted-hazard ratio 1.71, 95 % confidence interval: 1.14-2.56, p = 0.009). Patients with a hepatic T1-time ≥563 ms had a higher risk of CV events (log-rank p = 0.03).<br />Conclusion: Among stable patients with DCM, higher hepatic iron-corrected T1-time is associated with worse cardiac size and function and with higher rates of hospitalization for HF or CV death.<br />Condensed Abstract: Limited data exist regarding the clinical value of hepatic T1-time in patients with dilated cardiomyopathy (DCM) undergoing cardiac Magnetic Resonance imaging (MRI). We found that higher hepatic iron-corrected T1-time is associated with worse cardiac size and function, even after accounting for clinical confounders. Over a mean follow-up of 4.5 ± 1.8 years, higher hepatic iron-corrected T1-time was independently associated with a higher risk of hospitalization for heart failure or cardiovascular death. Among stable patients with DCM, the evaluation of liver tissue by cardiac MRI may provide useful clinical information for CV risk stratification.<br />Competing Interests: Conflict of Interest Disclosures The authors declare they have no conflict of interest<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Female
Male
Middle Aged
Retrospective Studies
Aged
Adult
Cross-Sectional Studies
Hospitalization statistics & numerical data
Linear Models
Stroke Volume
Heart Failure physiopathology
Heart Failure mortality
Cardiomyopathy, Dilated diagnostic imaging
Cardiomyopathy, Dilated physiopathology
Cardiomyopathy, Dilated mortality
Cardiomyopathy, Dilated complications
Magnetic Resonance Imaging
Liver diagnostic imaging
Liver pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0828
- Volume :
- 127
- Database :
- MEDLINE
- Journal :
- European journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38719725
- Full Text :
- https://doi.org/10.1016/j.ejim.2024.04.009