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Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study.
- Source :
-
Environment international [Environ Int] 2024 May; Vol. 187, pp. 108720. Date of Electronic Publication: 2024 May 05. - Publication Year :
- 2024
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Abstract
- Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFASs) influences neurodevelopment. Thyroid homeostasis disruption is thought to be a possible underlying mechanism. However, current epidemiological evidence remains inconclusive.<br />Objectives: This study aimed to explore the effects of prenatal PFAS exposure on the intelligence quotient (IQ) of school-aged children and assess the potential mediating role of fetal thyroid function.<br />Methods: The study included 327 7-year-old children from the Sheyang Mini Birth Cohort Study (SMBCS). Cord serum samples were analyzed for 12 PFAS concentrations and 5 thyroid hormone (TH) levels. IQ was assessed using the Wechsler Intelligence Scale for Children-Chinese Revised (WISC-CR). Generalized linear models (GLM) and Bayesian Kernel Machine Regression (BKMR) were used to evaluate the individual and combined effects of prenatal PFAS exposure on IQ. Additionally, the impact on fetal thyroid function was examined using a GLM, and a mediation analysis was conducted to explore the potential mediating roles of this function.<br />Results: The molar sum concentration of perfluorinated carboxylic acids (ΣPFCA) in cord serum was significantly negatively associated with the performance IQ (PIQ) of 7-year-old children (β = -6.21, 95 % confidence interval [CI]: -12.21, -0.21), with more pronounced associations observed among girls (β = -9.57, 95 % CI: -18.33, -0.81) than in boys. Negative, albeit non-significant, cumulative effects were noted when considering PFAS mixture exposure. Prenatal exposure to perfluorooctanoic acid, perfluorononanoic acid, and perfluorooctanesulfonic acid was positively associated with the total thyroxine/triiodothyronine ratio. However, no evidence supported the mediating role of thyroid function in the link between PFAS exposure and IQ.<br />Conclusions: Increased prenatal exposure to PFASs negatively affected the IQ of school-aged children, whereas fetal thyroid function did not serve as a mediator in this relationship.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Female
Child
Pregnancy
Male
Birth Cohort
Cohort Studies
Thyroid Hormones blood
Intelligence Tests
China
Maternal Exposure adverse effects
Fetal Blood chemistry
Alkanesulfonic Acids blood
Alkanesulfonic Acids toxicity
Prenatal Exposure Delayed Effects chemically induced
Fluorocarbons toxicity
Fluorocarbons blood
Intelligence drug effects
Thyroid Gland drug effects
Environmental Pollutants blood
Environmental Pollutants toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6750
- Volume :
- 187
- Database :
- MEDLINE
- Journal :
- Environment international
- Publication Type :
- Academic Journal
- Accession number :
- 38718676
- Full Text :
- https://doi.org/10.1016/j.envint.2024.108720