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History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment.
- Source :
-
Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4540-4550. Date of Electronic Publication: 2024 May 08. - Publication Year :
- 2024
-
Abstract
- Objectives: To investigate whether a history of traumatic brain injury (TBI) is associated with greater long-term grey-matter loss in patients with mild cognitive impairment (MCI).<br />Methods: 85 patients with MCI were identified, including 26 with a previous history of traumatic brain injury (MCI[TBI-]) and 59 without (MCI[TBI+]). Cortical thickness was evaluated by segmenting T1-weighted MRI scans acquired longitudinally over a 2-year period. Bayesian multilevel modelling was used to evaluate group differences in baseline cortical thickness and longitudinal change, as well as group differences in neuropsychological measures of executive function.<br />Results: At baseline, the MCI[TBI+] group had less grey matter within right entorhinal, left medial orbitofrontal and inferior temporal cortex areas bilaterally. Longitudinally, the MCI[TBI+] group also exhibited greater longitudinal declines in left rostral middle frontal, the left caudal middle frontal and left lateral orbitofrontal areas sover the span of 2 years (median = 1-2%, 90%HDI [-0.01%: -0.001%], probability of direction (PD) = 90-99%). The MCI[TBI+] group also displayed greater longitudinal declines in Trail-Making-Test (TMT)-derived ratio (median: 0.737%, 90%HDI: [0.229%: 1.31%], PD = 98.8%) and differences scores (median: 20.6%, 90%HDI: [-5.17%: 43.2%], PD = 91.7%).<br />Conclusions: Our findings support the notion that patients with MCI and a history of TBI are at risk of accelerated neurodegeneration, displaying greatest evidence for cortical atrophy within the left middle frontal and lateral orbitofrontal frontal cortex. Importantly, these results suggest that long-term TBI-mediated atrophy is more pronounced in areas vulnerable to TBI-related mechanical injury, highlighting their potential relevance for diagnostic forms of intervention in TBI.<br /> (© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Longitudinal Studies
Neuropsychological Tests
Cerebral Cortex diagnostic imaging
Cerebral Cortex pathology
Bayes Theorem
Cognitive Dysfunction etiology
Cognitive Dysfunction pathology
Cognitive Dysfunction diagnostic imaging
Brain Injuries, Traumatic diagnostic imaging
Brain Injuries, Traumatic pathology
Brain Injuries, Traumatic complications
Gray Matter diagnostic imaging
Gray Matter pathology
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 271
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 38717612
- Full Text :
- https://doi.org/10.1007/s00415-024-12369-2