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[The clinical features, survival analysis, and geriatric assessment of 85 patients with follicular lymphoma: a single-center study].
- Source :
-
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2024 Mar 14; Vol. 45 (3), pp. 233-241. - Publication Year :
- 2024
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Abstract
- Objective: To retrospectively analyze the clinical characteristics and prognosis of 85 newly diagnosed patients with follicular lymphoma (FL), as well as the prognostic value of comprehensive geriatric assessment (CGA) in patients with FL aged ≥ 60 years old. Methods: The clinical data and prognosis of 85 newly diagnosed FL patients admitted from August 2011 to June 2022 were collected. The clinical features, laboratory indicators, therapeutic efficacy, survival and prognostic factors of patients were statistically analyzed, and the prognosis of patients was stratified using various geriatric assessment tools. Results: ① The patients with FL were mostly middle-aged and older, with a median age of 59 (20-87) years, including 41 patients (48.2%) aged ≥60 years. The ratio of male to female was 1∶1.36. Overall, 77.6% of the patients were diagnosed with Ann Arbor stage Ⅲ-Ⅳ, and 17 cases (20.0%) were accompanied by B symptoms. Bone marrow involvement was the most common (34.1%). ②Overall, 71 patients received immunochemotherapy. The overall response rate was 86.6%, and the complete recovery rate was 47.1% of 68 evaluated patients. Disease progression or relapse in the first 2 years was observed in 23.9% of the patient. Overall, 14.1% of the patients died during follow-up. ③Of the 56 patients receiving R-CHOP-like therapies, the 3-year and 5-year progression-free survival (PFS) rates were 85.2% and 72.8%, respectively, and the 3-year and 5-year overall survival (OS) rates were 95.9% and 88.8%, respectively. The univariate analysis showed that age ≥60 years old ( HR =3.430, 95% CI 1.256-9.371, P =0.016), B symptoms ( HR =5.030, 95% CI 1.903-13.294, P =0.016), Prognostic Nutritional Index (PNI) <45.25 ( HR =3.478, 95% CI 1.299-9.310, P =0.013), Follicular Lymphoma International Prognostic Index (FLIPI) high-risk ( HR =2.918, 95% CI 1.074-7.928, P =0.036), and PRIMA-prognostic index (PRIMA-PI) high-risk ( HR =2.745, 95% CI 1.057-7.129, P =0.038) significantly predicted PFS. Moreover, age ≥60 years old and B symptoms were independent risk factors for PFS. Progression of disease within 24 months (POD24) significantly predicted OS in the univariate analysis. Conclusions: FL is more common among middle-aged and older women. Age, B symptoms, PNI score, FLIPI high-risk, PRIMA-PI high-risk, and POD24 influenced PFS and OS. The CGA can be used for treatment selection and risk prognostication in older patients with FL.
- Subjects :
- Humans
Aged
Male
Female
Middle Aged
Retrospective Studies
Prognosis
Aged, 80 and over
Survival Analysis
Adult
Survival Rate
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Lymphoma, Follicular diagnosis
Lymphoma, Follicular mortality
Lymphoma, Follicular therapy
Geriatric Assessment methods
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-2727
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 38716594
- Full Text :
- https://doi.org/10.3760/cma.j.cn121090-20230815-00067