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TRANSCRIPTOMIC DIFFERENCES IN PERIPHERAL MONOCYTE POPULATIONS IN SEPTIC PATIENTS BASED ON OUTCOME.

Authors :
Barrios EL
Rincon JC
Willis M
Polcz VE
Leary JR
Darden DB
Balch JA
Larson SD
Loftus TJ
Mohr AM
Wallet S
Brusko MA
Balzano-Nogueira L
Cai G
Sharma A
Upchurch GR Jr
Kladde MP
Mathews CE
Maile R
Moldawer LL
Bacher R
Efron PA
Source :
Shock (Augusta, Ga.) [Shock] 2024 Aug 01; Vol. 62 (2), pp. 208-216. Date of Electronic Publication: 2024 May 02.
Publication Year :
2024

Abstract

Abstract: Postsepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness with suboptimal outcomes. The underlying immunological response that determines these clinical trajectories remains poorly defined at the transcriptomic level. As classical and nonclassical monocytes are key leukocytes in both the innate and adaptive immune systems, we sought to delineate the transcriptomic response of these cell types. Using single-cell RNA sequencing and pathway analyses, we identified gene expression patterns between these two groups that are consistent with differences in TNF-α production based on clinical outcome. This may provide therapeutic targets for those at risk for chronic critical illness in order to improve their phenotype/endotype, morbidity, and long-term mortality.<br />Competing Interests: The authors report no conflicts of interest.<br /> (Copyright © 2024 by the Shock Society.)

Details

Language :
English
ISSN :
1540-0514
Volume :
62
Issue :
2
Database :
MEDLINE
Journal :
Shock (Augusta, Ga.)
Publication Type :
Academic Journal
Accession number :
38713581
Full Text :
https://doi.org/10.1097/SHK.0000000000002379