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Norditerpenoid alkaloids from Aconitum refractum var. circinatum as autophagy inducers.
- Source :
-
Phytochemistry [Phytochemistry] 2024 Jul; Vol. 223, pp. 114115. Date of Electronic Publication: 2024 May 06. - Publication Year :
- 2024
-
Abstract
- A total of twenty-two diterpenoid alkaloids, including ten unprecedented ones, namely refractines C-L, were isolated from the roots of Aconitum refractum (Finet et Gagnep.) Hand.-Mazz. Refractine C was the first example of a natural diterpenoid alkaloid wherein C-19 is linked to N position by an oxaziridine ring. Refractine L was a rare glycosidic diterpenoid alkaloid with fructofuranoside. Most of the isolated compounds obtained from a previous study were screened for their anti-inflammatory and myocardial protective activities. The autophagy-inducing effects of some of these compounds on RAW 264.7 cells were evaluated by assessing the expression of microtubule-associated protein 1 light chain 3 (LC3-II/LC3-I). Results revealed that some compounds exerted varying levels of inhibitory effects on the proliferative activity of RAW 264.7 cells.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interest.<br /> (Copyright © 2024. Published by Elsevier Ltd.)
- Subjects :
- Mice
Animals
RAW 264.7 Cells
Cell Proliferation drug effects
Molecular Structure
Structure-Activity Relationship
Dose-Response Relationship, Drug
Plant Roots chemistry
Aconitum chemistry
Autophagy drug effects
Alkaloids pharmacology
Alkaloids isolation & purification
Alkaloids chemistry
Diterpenes pharmacology
Diterpenes chemistry
Diterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 223
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38710377
- Full Text :
- https://doi.org/10.1016/j.phytochem.2024.114115