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Trackable Liposomes for In Vivo Delivery Tracing toward Personalized Medicine Care under NIR Light on Skin Tumor.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2024 May 20; Vol. 7 (5), pp. 3190-3201. Date of Electronic Publication: 2024 May 06. - Publication Year :
- 2024
-
Abstract
- We report an near-infrared (NIR)-trackable and therapeutic liposome with skin tumor specificity. Liposomes with a hydrodynamic diameter of ∼20 nm are tracked under the vein visualization imaging system in the presence of loaded paclitaxel and NIR-active agents. The ability to track liposome nanocarriers is recorded on the tissue-mimicking phantom model and in vivo mouse veins after intravenous administration. The trackable liposome delivery provides in vitro and in vivo photothermal heat (∼40 °C) for NIR-light-triggered area-specific chemotherapeutic release. This approach can be linked with a real-time vein-imaging system to track and apply area-specific local heat, which hitchhikes liposomes from the vein and finally releases them at the tumor site. We conducted studies on mice skin tumors that indicated the disappearance of tumors visibly and histologically (H&E stains). The ability of nanocarriers to monitor after administration is crucial for improving the effectiveness and specificity of cancer therapy, which could be achieved in the trackable delivery system.
- Subjects :
- Animals
Mice
Materials Testing
Biocompatible Materials chemistry
Particle Size
Humans
Drug Delivery Systems
Drug Screening Assays, Antitumor
Liposomes chemistry
Infrared Rays
Skin Neoplasms pathology
Skin Neoplasms drug therapy
Skin Neoplasms therapy
Precision Medicine
Paclitaxel chemistry
Paclitaxel administration & dosage
Paclitaxel pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2576-6422
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 38709861
- Full Text :
- https://doi.org/10.1021/acsabm.4c00203